Table 3

List of genes spotted twice on the microarray filter which evinced a significant change in their mRNA expression in TGFβ-treated T84 cells compared to T84 cells grown solely in collagen I gel (= TGFβ-treated vs. control).
Gene ontology class
 Gene name
 GenBank no
 chromosomal location
 TGFβ-treated vs. control








ratio
 SD
 ratio
 SD
A
 FDPS: farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
 T66907
T65907
 1q22
 0.29↓
 (±0.24)
 0.57↓
 (±0.45)
A
 GRP58: glucose regulated protein, 58 kD,
 R33030
 15q15
 0.56↓
 (±0.12)
 0.60↓
 (±0.16)
C
 BAP1: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
 H09065
 3p21.31-p21.2
 0.72↓
 (±0.19)
 0.68↓
 (±0.17)
D
 DRAP1: DR1-associated protein 1
 AA421977
AA406285
 11q13.3
 0.53↓
 (±0.22)
 0.60↓
 (±0.19)
D
 AEBP1: AE binding protein 1
 AA490462
AA490684
 7p13
 0.48↓
 (±0.34)
 0.60↓
 (±0.32)
D
 ZNF161: zinc finger protein 161
 AA232647
 17q23.3
 0.71↓
 (±0.13)
 0.75↓
 (±0.11)
E
 IGF2: insulin-like growth factor 2 (somatomedin A)
 N54596
 11p15.5
 0.57↓
 (±0.16)
 0.63↓
 (±0.17)
E
 MAST1: microtubule associated serine/threonine kinase 1
 AA479623
 19p13.2
 0.51↓
 (±0.18)
 0.59↓
 (±0.48)
E
 EGFR: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
 R35665
W48713
 7p12
 0.47↓
 (±0.04)
 0.75↓
 (±0.13)
E
 EPHA1: ephrin receptor EphA1
 N90246
 7q34
 0.66↓
 (±0.10)
 0.63↓
 (±0.07)
E
 RNTRE: related to the N terminus of tre
 AA281057
AA281137
 10p13
 0.78↓
 (±0.25)
 0.71↓
 (±0.21)
E
 EFNB2: ephrin-B2
 AA461424
AA461108
 13q33
 0.77↓
 (±0.20)
 0.79↓
 (±0.06)
F
 UBE2N: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
 AA490124
 12q21.33
 0.76↓
 (±0.16)
 0.79↓
 (±0.17)
I
 ATP6V0A1: ATPase, H+ transporting, lysosomal V0 subunit a isoform 1
 AA427472
 17q21
 0.65↓
 (±0.02)
 0.62↓
 (±0.08)

Genes are sorted by functional classification. A: Cellular metabolism (GO:0044237), Metabolism (other than energy metabolism), C: Nucleic acid binding (GO:0003676), D: Transcription regulator activity (GO:0030528), E: Signal transducer activity (GO:0004871), Signal transduction (GO:0007165) and Cell communication (GO:0007154), F: Cellular macromolecule metabolism (GO:0044260), I: Transport (GO:0006810), Downward arrow indicates down-regulated mRNA expression, bold indicates genes that have significant alteration in gene expression. Ratio is mean value calculated from three separate microarray experiments; SD is the standard deviation between separate experiments.

Juuti-Uusitalo et al. BMC Genomics 2006 7:279   doi:10.1186/1471-2164-7-279