Allele frequencies in the offspring pool predicted by pooled analysis and corrected with k (y-axis), plotted against the true allele frequencies of this sample (x-axis). The correlation coefficient is r = 0.997. Note that the coefficient k was derived from parental data (see methods) and then applied to the data obtained for children. Any errors in estimating the parental allele frequencies are incorporated in the estimate of k and therefore the estimate of the allele frequency in offspring includes the measurement errors from both samples.
Kirov et al. BMC Genomics 2006 7:27 doi:10.1186/1471-2164-7-27