|
ToxArray™ data normalized using EC: Overall adjusted p after exposure to PB and fold changes (relative to Control) and pairwise p-values at each dose for each gene (probe) that showed differential expression. |
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| Control versus 100 mg/kg |
Control versus 10 mg/kg |
Control versus 1 mg/kg |
James-Stein F-Test † |
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|
|
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| Gene(probe) Name> |
Full name |
GenBank |
Fold change |
Pairwise P-value |
Fold change |
Pairwise P-value |
Fold change |
Pairwise P-value |
Overall P-value |
|
|
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| Cyp2b9 |
cytochrome P450, 2b9, phenobarbitol inducible, type a, |
NM_010000 |
8.29 |
0.0000 |
3.22 |
0.0000 |
1.16 |
0.8087 |
0.0000 |
| Cyp2b10 |
Cytochrome P450, 2b10, phenobarbitol inducible, type b |
NM_009998 |
5.10 |
0.0000 |
2.95 |
0.0000 |
-1.08 |
0.8437 |
0.0000 |
| Gdf15 |
growth differentiation factor 15 |
NM_011819 |
2.83 |
0.0000 |
1.25 |
0.3499 |
1.07 |
0.8667 |
0.0000 |
| Gstm3 |
glutathione S- transferase mu 3 (EC 2.5.1.18) |
J03953 |
2.16 |
0.0000 |
1.04 |
0.8458 |
1.30 |
0.4200 |
0.0000 |
| Lpin1 |
lipin 1, alias fatty liver dystrophy |
NM_015763 |
-1.94 |
0.0009 |
-1.18 |
0.3932 |
-1.08 |
0.8437 |
0.0039 |
| Gadd45b |
growth arrest and DNA-damage-inducible 45 beta |
NM_008655 |
1.92 |
0.0000 |
1.08 |
0.6595 |
-1.13 |
0.7038 |
0.0000 |
| Gadd45a |
growth arrest and DNA damage inducible |
NM_007836 |
1.66 |
0.0003 |
1.20 |
0.2245 |
-1.24 |
0.4200 |
0.0000 |
| Por |
NADPH cytochrome p450 oxidoreductase |
NM_008898 |
1.66 |
0.0806 |
1.22 |
0.3847 |
1.04 |
0.9392 |
0.0402 |
| Tieg1 |
TGFB inducible early growth response 1 |
NM_013692 |
-1.64 |
0.0011 |
-1.23 |
0.1983 |
-1.21 |
0.5440 |
0.0062 |
| Gstm1 |
glutathione S-transferase mu 1 |
NM_010358 |
1.63 |
0.2258 |
-1.14 |
0.6339 |
-1.03 |
0.9622 |
0.0377 |
| sult1c2 |
sulfotransferase family 1C, member 2 |
NM_026935 |
1.55 |
0.0044 |
1.16 |
0.3501 |
1.21 |
0.5440 |
0.0350 |
| AhR |
rat Ah receptor |
NM_013464 |
1.48 |
0.0423 |
-1.05 |
0.7919 |
-1.12 |
0.7389 |
0.0039 |
| Chk |
choline kinase |
NM_013490 |
-1.45 |
0.0041 |
-1.31 |
0.0876 |
1.02 |
0.9443 |
0.0039 |
| Adcy6 |
adenylate cyclase 6 |
NM_007405 |
-1.43 |
0.0003 |
-1.20 |
0.1165 |
-1.05 |
0.7925 |
0.0004 |
| Bhmt |
betaine homocysteine methyl transferase |
NM_016668 |
-1.40 |
0.2598 |
-1.16 |
0.4362 |
1.19 |
0.6392 |
0.0385 |
| gstm2 |
glutathione S-transferase, mu 2 |
NM_008183 |
1.39 |
0.0313 |
-1.10 |
0.4647 |
-1.01 |
0.9754 |
0.0054 |
| Dusp6 |
dual specificity phosphatase 6 |
NM_026268 |
1.39 |
0.0852 |
1.23 |
0.2007 |
-1.07 |
0.8288 |
0.0181 |
| Lbp |
Lipopolysaccharide binding protein |
NM_008489 |
1.39 |
0.0104 |
1.15 |
0.2591 |
1.32 |
0.1249 |
0.0379 |
| Rbp1 |
retinol binding protein 1, cellular |
NM_011254 |
1.34 |
0.2364 |
-1.19 |
0.2941 |
1.00 |
0.9976 |
0.0101 |
| Ephx1 |
epoxide hydrolase 1, microsomal; Eph1, Eph-1, AI195553 |
NM_010145 |
1.33 |
0.0486 |
-1.08 |
0.5597 |
1.05 |
0.8358 |
0.0181 |
| Gsta4 |
Glutathione S-transferase, alpha 4 |
NM_010357 |
1.32 |
0.1312 |
-1.14 |
0.3506 |
-1.10 |
0.7389 |
0.0045 |
| Ube2b |
ubiquitin conjugating enzyme, E2B (RAD 6 homoly S.cerevisea) |
NM_009458 |
-1.23 |
0.0358 |
-1.01 |
0.8808 |
1.00 |
0.9935 |
0.0350 |
| Copeb |
core promoter element binding protein |
NM_011803 |
-1.21 |
0.8557 |
-1.28 |
0.1810 |
-1.44 |
0.1569 |
0.0471 |
| Hao1 |
hydroxyacid oxidase |
NM_010403 |
-1.20 |
0.8890 |
1.12 |
0.5641 |
1.38 |
0.4200 |
0.0402 |
| Anpep |
aminopeptidase N |
NM_008486 |
1.20 |
0.4022 |
-1.20 |
0.1456 |
-1.05 |
0.8153 |
0.0070 |
| Egfr |
epidermal growth factor receptor |
NM_007912 |
-1.18 |
0.7714 |
-1.04 |
0.7719 |
1.21 |
0.4200 |
0.0429 |
| Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
NM_008149 |
-1.16 |
0.2258 |
-1.00 |
0.9864 |
1.13 |
0.4200 |
0.0068 |
| Olfr1161 |
olfactory receptor 1161 |
NM_146848 |
1.13 |
0.8471 |
1.30 |
0.0420 |
1.27 |
0.1191 |
0.0300 |
| Keap1 |
Kelch-like ECH-assoc. protein 1, cytosolic inhibitor of NRF2) |
NM_016679 |
-1.12 |
0.8821 |
-1.24 |
0.1165 |
-1.38 |
0.0941 |
0.0181 |
| Ssrp1 |
Structure specific recognition protein 1 |
XM_130271 |
-1.10 |
0.8932 |
-1.13 |
0.3501 |
-1.34 |
0.1191 |
0.0121 |
| mpg |
N-methylpurine-DNA glycosylase |
NM_010822 |
1.09 |
0.8894 |
1.30 |
0.0420 |
1.07 |
0.7269 |
0.0417 |
| Ape2 |
AP endonuclease 2 |
NM_029943 |
-1.04 |
0.9530 |
-1.04 |
0.8232 |
-1.37 |
0.3673 |
0.0385 |
| Ripk1 |
receptor (TNFRSF)-interacting serine-threonine kinase 1 |
NM_009068 |
-1.03 |
0.9565 |
-1.10 |
0.5255 |
-1.43 |
0.1191 |
0.0490 |
| Nme2 |
expressed in non-metastatic cells 2, protein |
NM_008705 |
1.02 |
0.9737 |
-1.24 |
0.2245 |
-1.12 |
0.7406 |
0.0238 |
| Vegfb(2) |
vascular endothelial growth factor B |
NM_011697 |
-1.00 |
0.9944 |
-1.21 |
0.1279 |
-1.32 |
0.1191 |
0.0080 |
|
* Data ordered by fold-change in 100 mg/ml dose. There were no significant genes in 0.1 mg/ml dose. † Overall treatment effect | |||||||||
Yauk et al. BMC Genomics 2006 7:266 doi:10.1186/1471-2164-7-266 |
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