Some microRNA families, such as the mir-10 and mir-100 (left), exhibit very similar mature miRNA sequences, while their precursor sequences show little sequence similarity. Right: A table of alignment z-score for both mature and precursor sequences summarizes the four most likely candidates for distance homologies. While the mir-8/mir-429 pair is most likely a true homolog, the other three pairs are unconvincing, see text.
Hertel et al. BMC Genomics 2006 7:25 doi:10.1186/1471-2164-7-25