Table 5

The top 25 genes exhibiting decreased mRNA abundance 2 hours post activation.

Clone
E value
Accession No.
Gene Symbol
Gene
Fold Decrease
FDRmax
P value

C0006018h16
0.0
NM_031483
ITCH
Itchy homolog E3 ubiquitin protein ligase
-5.36
2.55E-10
2.79E-12
MARC_2BOV_14N13
e-151
XM_582744
IL16
Interleukin 16
-4.94
9.35E-10
1.41E-11
C0006011p15
0.0
NM_003400
XPO1
Exportin 1
-4.11
3.28E-03
4.70E-04
C0006011d04
e-112
NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
-4.05
4.14E-05
2.88E-06
C0005202b11
0.0
NM_006565
CTCF
CCCTC-binding factor
-3.83
9.04E-06
4.90E-07
C0006014p20
0.0
NM_005642
TAF7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
-3.74
7.65E-09
1.61E-10
MARC_1BOV_107K4
0.0
XM_584158
CCR2
Chemokine (C-C motif) receptor 2
-3.70
4.81E-06
2.40E-07
C0005203a5
6.00E-54
NM_032804
C10orf22
Chromosome 10 open reading frame 22
-3.69
2.77E-04
2.68E-05
C0006005d04
0.0
XM_588702
UNG
Uracil-DNA glycosylase
-3.62
4.24E-10
5.00E-12
C0007385D18
0.0
BM087483
-
EST
-3.60
2.00E-03
2.63E-04
C0006007o03
e-153
NM_016046
EXOSC1
Exosome component 1
-3.51
6.69E-07
2.57E-08
C0006019m08
0.0
XM_868169
-
Hypothetical protein LOC616204
-3.51
8.67E-06
4.67E-07
C0005205c2
2.00E-70
NM_024939
RBM35B
RNA binding motif protein 35B
-3.50
7.22E-08
2.15E-09
C0005207d22
0.0
NM_013444
UBQLN2
Ubiquilin 2
-3.48
1.36E-08
3.13E-10
C0005198j2
7.00E-58
NM_139014
MAPK14
Mitogen-activated protein kinase 14 (p38)
-3.41
1.36E-08
3.15E-10
C0006005h08
0.0
NM_052911
ESCO1
Establishment of cohesion 1 homolog 1
-3.36
9.89E-06
5.48E-07
C0005202l16
4.00E-42
XM_545369
C6orf32
Chromosome 6 open reading frame 32
-3.32
2.43E-10
2.61E-12
MARC_2BOV_105E23
e-119
NM_153425
TRADD
TNFRSF1A-associated via death domain
-3.18
3.95E-07
1.45E-08
C0006007o20
e-111
NM_001001806
ZFP36L2
Zinc finger protein 36, C3H type-like 2
-3.18
3.22E-09
5.75E-11
C0005209h6
e-108
NM_006163
NFE2
Nuclear factor (erythroid-derived 2), 45kDa
-3.13
3.40E-06
3.27E-07
C0006019p19
e-106
XM_868699
TOB2
Transducer of ERBB2, 2
-3.13
8.37E-07
3.31E-08
C0005202g13
0.0
AV594592
-
EST
-3.11
7.31E-04
8.25E-05
C0005208j1
0.0
CB221804
-
EST
-3.10
6.65E-05
5.18E-06
C0006012f10
1.00E-67
NM_145037
FAM55C
Family with sequence similarity 55, member C
-3.08
1.03E-11
6.98E-14
C0005208h20
0.0
CB420023
-
EST
-3.01
1.67E-05
9.91E-07

Summary of the top 25 genes exhibiting decreased mRNA abundance 2 hours post activation, including clone name, accession number, e-value and identity of the best BLAST match and average fold change. The P and FDRmax values denote the probability from the moderated t-test and the Benjamini and Hochberg false discovery rate values respectively from the analysis of the resting cell values compared to the average activated sample values (Pre v Post).

Jensen et al. BMC Genomics 2006 7:224   doi:10.1186/1471-2164-7-224