|
Gene ontology classification of the HCC differentially expressed genes |
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| Up-regulated genes* |
Down-regulated genes* |
P-value |
|
|
|
|||
| Cell cycle |
19 |
4 |
0.052 |
| Regulation of apoptosis |
8 |
1 |
0.121 |
| Transcription & regulation of transcription |
44 |
13 |
0.040 |
| Signal transduction |
48 |
24 |
0.777 |
| Cell organizaiton & biogenesis |
28 |
9 |
0.109 |
| Purine & pyrimidine metabolism |
80 |
26 |
0.009 |
| Protein metabolism |
89 |
27 |
0.002 |
| Nuclear © |
89 |
26 |
0.001 |
| Chromosome © |
8 |
3 |
0.432 |
| Cytoskeleton © |
18 |
5 |
0.128 |
| Ubiquitin ligase complex © |
7 |
1 |
0.170 |
| Complement & coagulation cascades |
0 |
11 |
0.000 |
| Response to wounding |
4 |
12 |
0.011 |
| Defense response |
16 |
24 |
0.000 |
| Response to external biotic stimuli |
10 |
15 |
0.007 |
| Immune response |
14 |
21 |
0.001 |
| Cell ion homeostasis |
1 |
5 |
0.021 |
| Microsome © |
2 |
6 |
0.442 |
| Peroxisome © |
1 |
4 |
0.051 |
| Extra-cellular space © |
4 |
15 |
0.000 |
|
*Based on 360 and 202 informative up- and down-regulated genes identified using the SSH/microarray in HCC. © cellular components, based on 207 and 110 informative up- and down-regulated genes in human HCC, respectively. P value was determined by Fisher's exact test. | |||
Pan et al. BMC Genomics 2006 7:131 doi:10.1186/1471-2164-7-131 |
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