ARN1 Regulatory module. On the left, a QTG network built from confident pairwise relationships with respect to the seed ARN1 gene involved in iron homeostasis. Undirected edges indicate significant full model scores, but not significant genotype reduced-model scores. Directed edges identify causal relationships. Shaded nodes are known to be involved in iron homeostasis. On the right, a BN constructed from discretized gene expression alone. 2,3, and 4 bin discretizations yielded the same results.
Kulp and Jagalur BMC Genomics 2006 7:125 doi:10.1186/1471-2164-7-125