Table 5 |
||||||
|
Segment and tissue specificity of transporters along the A-P and crypt-villus axis. |
||||||
|
Transporter |
Segment-Specificitya,M |
Segment-Specificitya,R |
Tissue-Specificityb |
|||
|
|
||||||
|
Duodenum |
Jejunum |
Ileum |
Colon |
|||
|
|
||||||
|
Abca1 |
D=J=I=C |
J=I=C>D |
Crypts>Villi |
ND |
ND |
ND |
|
Abcc1 |
D=J=I=C |
I=C>D=J |
Crypts>Villi |
Crypts>Villi |
Crypts>Villi |
ND |
|
Abcc3 |
D=C>J=C>I=C |
I=C>D=J |
ND |
Crypts>Villi |
ND |
Crypts>Villi |
|
Abcg8 |
J>I=D>C |
D=J=I>C |
ND |
Villi>Crypts |
Villi>Crypts |
ND |
|
Slc10a2 |
I>C>D=J |
I>C>D=J |
ND |
ND |
Villi>Crypts |
ND |
|
Slc28a2 |
D>J>I>C |
D=J=I>C |
ND |
Villi>Cryptsx |
Villi>Cryptsx |
ND |
|
Slc2a1 |
C>D=J=I |
C>I>D=J |
ND |
Crypts>Villi |
Crypts>Villi |
Crypts>Villix |
|
Slc34a2 |
I>C>J>D |
I>C=J>D |
ND |
Villi>Crypts |
Villi>Crypts |
Villi>Crypts |
|
Slc5a8 |
C>I>D=J |
C=I>J>D |
ND |
Villi>Crypts |
ND |
ND |
|
|
||||||
|
aExpression in the four intestinal segments (D, J, I, C) was measured in whole tissue using microarrays (M) and RT-PCR (R) (n = 3, p ≤ 0.05). bTissue specificity was determined in laser dissected crypts and villi (n = 5, where p ≤ 0.05 or if indicated with a superscript "*" p ≤ 0.10). "ND" indicates that no significant difference in expression levels were measured between the crypt and villus epithelial cells. |
||||||
|
Anderle et al. BMC Genomics 2005 6:69 doi:10.1186/1471-2164-6-69 |
||||||
