Table 2

Additional Pfam domains on trypanosomatid ePKs

Pfam

Tba

Tc

Lm

TriTrypb

Other kinomesb

Comments


Armadillo

0

1

1

ULK

NEK, STE11, ULK

related to HEAT

B-box Zn finger

0

0

1

NEK

nd

Zn binding

C1-like

0

1

1

AGC

AGC

possible diacylglyerol binding

cap-gly

1

1

1

CAMK

VPS15

cytoskeleton associated

cNMP binding

0

1

2

STE

AGC

cyclic nucleotide binding

EF Hand

2

2

2

CAMK

CAMK

Calcium binding

FHA

1

2

4

CAMK, STE

CAMK

phosphopeptide binding

FYVE

1

2

1

AGC

nd

Zn binding

HAMP

0

1

0

STE

nd

in diverse signaling proteins

HEAT

1

1

0

ULK

VPS15

protein interaction

HECT

0

0

1

unique

nd

ubiquitin transferase

Kelch

1

0

0

unique

nd

propeller structure

LRR

1

1

1

CAMKK

TK, TKL, plantrk

protein interaction

MORN

1

1

1

STE

TKL, unique

unknown function

PAS

1

1

1

STE

CAMK, TKL

signal sensor

PH

6

7

6

AGC, NEK

AGC, CAMK, STE20

Phosphatidylinositol binding

PKC-Cterm

0

0

2

AGC

AGC

found on protein kinases

POLO

1

1

1

POLO

POLO

POLO kinase region

PX

1

1

1

AGC

AGC

phosphoinositide binding

RWD

1

0

0

PEK

PEK

unknown function

TPR2

0

2

1

STE, unique

plantrk

protein interaction

zf-C2H2

2

1

1

unique

AUR

zinc binding


a The number of genes bearing the indicated Pfam domain.

b Classification of ePKs bearing the designated domain in the TriTryps or other kinomes (as detected in S. cerevisiae, Schizosaccharomyces pombe, P. falciparum, C. elegans, D. melanogaster, A. thaliana, and Oryza sativa) using the web tools at the Kinases in Genomes (KING) website [81]. The plantrk group is comprised of serine/threonine receptor kinases present in plant; nd, none detected.

Parsons et al. BMC Genomics 2005 6:127   doi:10.1186/1471-2164-6-127

Open Data