BMC Genomics

official impact factor 4.21

Open Access

Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing

Shobhit Gupta*, Dorothea Zink, Bernhard Korn, Martin Vingron and Stefan A Haas

BMC Genomics 2004, 5:72 doi:10.1186/1471-2164-5-72

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BioMed Central: 9 citations

Proceedings   Open Access Highly Accessed

Towards reliable isoform quantification using RNA-SEQ data

Brian E Howard, Steffen Heber BMC Bioinformatics 2010, 11(Suppl 3):S6 (29 April 2010)

Methodology article   Open Access Highly Accessed

Differential splicing using whole-transcript microarrays

Mark D Robinson, Terence P Speed BMC Bioinformatics 2009, 10:156 (22 May 2009)

The Affymetrix GeneChip microarray platform, widely used to assay gene expression, can also detect differential splicing events with the help of a new statistical method called FIRMAGene that analyses information from poorly fitting adjacent probes.

Research article   Open Access Highly Accessed

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays

Hannah C Cheung, Keith A Baggerly, Spiridon Tsavachidis, Linda L Bachinski, Valerie L Neubauer, Tamara J Nixon, Kenneth D Aldape, Gilbert J Cote, Ralf Krahe BMC Genomics 2008, 9:216 (12 May 2008)

Research article   Open Access Highly Accessed

Annotation of expressed sequence tags for the East African cichlid fish Astatotilapia burtoni and evolutionary analyses of cichlid ORFs

Walter Salzburger, Susan CP Renn, Dirk Steinke, Ingo Braasch, Hans A Hofmann, Axel Meyer BMC Genomics 2008, 9:96 (25 February 2008)

Database   Open Access Highly Accessed

A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of human alternative splicing variants

Pierre de la Grange, Martin Dutertre, Margot Correa, Didier Auboeuf BMC Bioinformatics 2007, 8:180 (4 June 2007)

Research   Open Access Highly Accessed

Discovery of tissue-specific exons using comprehensive human exon microarrays

Tyson A Clark, Anthony C Schweitzer, Tina X Chen, Michelle K Staples, Gang Lu, Hui Wang, Alan Williams, John E Blume Genome Biology 2007, 8:R64 (24 April 2007)

Comprehensive exon microarrays with a simple intra-gene normalization algorithm were used to detect human tissue-specific alternative splicing events, suggesting significant expression outside of known exons and well annotated genes and a high frequency of alternative splicing events.

Research article   Open Access

Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression

Heike Pospisil, Alexander Herrmann, Kristine Butherus, Stefan Pirson, Jens G Reich, Wolfgang Kemmner BMC Genomics 2006, 7:148 (13 June 2006)

Research article   Open Access

Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

Vladimir N Babenko, Malay K Basu, Fyodor A Kondrashov, Igor B Rogozin, Eugene V Koonin BMC Cancer 2006, 6:36 (9 February 2006)

Genome-wide analysis of probable somatic mutations in normal and malignant tissue suggests that positive selection for gain of function may affect a number of genes during tumorigenesis.

Software   Open Access

Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration

Erdahl T Teber, Edward Crawford, Kent B Bolton, Derek Van Dyk, Peter R Schofield, Vimal Kapoor, W Bret Church BMC Bioinformatics 2006, 7:33 (23 January 2006)