Table 4 |
|||||||
|
Number of genes mapped to retinal disease loci |
|||||||
|
Disease |
Chr. |
Flanking DNA marker |
Size of locus (Mb) |
No. of SGPs (n = 43,109) |
No. of retinome transcripts a) (n = 13,307) |
No. of "retinome-enriched" transcripts (n = 5,051) |
|
|
|
|||||||
|
AA |
11 |
D11S1323 |
D11S902 |
11.21 |
213 |
65 |
13 |
|
AIED |
X |
DXS7 |
DXS72 |
37.33 |
479 |
129 |
49 |
|
AXPC1 |
1 |
D1S2692 |
D1S414 |
3.00 |
43 |
7 |
3 |
|
BBS3 |
3 |
D3S1603 |
D3S1271 |
2.28 |
28 |
10 |
1 |
|
BBS5 |
2 |
D2S142 |
D2S326 |
16.81 |
353 |
50 |
24 |
|
BCD |
4 |
D4S3051 |
D4S1652 |
2.06 |
17 |
2 |
1 |
|
CACD |
17 |
D17S1810 |
CHLC.GAT7B03 |
3.17 |
118 |
76 |
36 |
|
COD2 |
X |
DXS292 |
DXS1113 |
6.1 |
37 |
5 |
3 |
|
COD4 |
X |
DXS10042 |
DXS8060 |
32.44 |
436 |
117 |
45 |
|
CORD1 |
18 |
marker position not available |
- |
- |
- |
- |
|
|
CORD4 |
17 |
marker position not available |
- |
- |
- |
- |
|
|
CORD8 |
1 |
D1S442 |
D1S2681 |
19.86 |
485 |
222 |
74 |
|
CORD9 |
8 |
D8S1820 |
D8S532 |
12.79 |
179 |
43 |
16 |
|
CRV |
3 |
D3S3564 |
D3S1578 |
11.2 |
271 |
157 |
72 |
|
CYMD |
7 |
D7S435 |
D7S526 |
1.56 |
25 |
13 |
7 |
|
EVR3 |
11 |
GATA34E08 |
D11S4102 |
14.00 |
192 |
35 |
13 |
|
LCA3 |
14 |
D14S606 |
D14S610 |
5.95 |
178 |
36 |
15 |
|
LCA5 |
6 |
D6S1551 |
D6S1694 |
36.08 |
541 |
263 |
93 |
|
LCA9 |
1 |
D1S1612 |
D1S228 |
5.52 |
130 |
51 |
22 |
|
MCDR1 |
6 |
D6S249 |
D6S1671 |
2.44 |
45 |
2 |
0 |
|
MCDR2 |
4 |
D4S3023 |
D4S3022 |
21.00 |
253 |
57 |
20 |
|
MCDR3 |
5 |
D5S1981 |
D5S2031 |
19.94 |
184 |
36 |
14 |
|
MCDR4 |
14 |
D14S261 |
- |
10.00 b) |
58 |
11 |
4 |
|
MRST |
15 |
D15S211 |
D15S152 |
4.70 |
106 |
24 |
11 |
|
OPA2 |
X |
DXS993 |
DXS991 |
14.31 |
245 |
69 |
24 |
|
OPA4 |
18 |
D18S34 |
D18S548 |
2.55 |
23 |
3 |
1 |
|
PRD |
X |
MAOB |
DXS426 |
3.92 |
67 |
18 |
6 |
|
RCD1 |
6 |
marker position not available |
- |
- |
- |
- |
|
|
RNANC |
10 |
D10S1225 |
D10S1418 |
5.76 |
58 |
9 |
2 |
|
ROA1 |
8 |
D8S1702 |
D8S1794 |
11.87 |
150 |
30 |
13 |
|
RP6 |
X |
DXS28 |
DXS164 |
4.92 |
60 |
4 |
2 |
|
RP17 |
17 |
D17S1607 |
D17S948 |
7.18 |
130 |
44 |
17 |
|
RP22 |
16 |
D16S287 |
D16S420 |
6.33 |
92 |
40 |
14 |
|
RP23 |
X |
DXS1223 |
DXS7161 |
10.51 |
140 |
30 |
15 |
|
RP24 |
X |
DXS8094 |
DXS8043 |
7.75 |
74 |
6 |
3 |
|
RP28 |
2 |
D1S1337 |
D2S286 |
45.78 |
674 |
194 |
68 |
|
RP29 |
4 |
D4S3035 |
D4S2417 |
3.66 |
28 |
5 |
2 |
|
STGD4 |
4 |
D4S1582 |
D4S2397 |
16.56 |
187 |
33 |
10 |
|
USH1A |
14 |
D14S99E |
D14S292 |
6.98 |
134 |
44 |
18 |
|
USH1E |
21 |
D21S1905 |
D21S1913 |
11.48 |
77 |
19 |
10 |
|
USH2B |
3 |
D3S1578 |
D3S3658 |
12.80 |
287 |
161 |
74 |
|
USH2C |
5 |
D5S428 |
D5S433 |
18.54 |
269 |
34 |
13 |
|
VRNI |
11 |
INT2 |
D11S873 |
22.41 |
311 |
89 |
37 |
|
WFS2 |
4 |
D4S2366 |
D4S3023 |
2.18 |
26 |
10 |
5 |
|
WGN1 |
5 |
D5S626 |
D5S2103 |
7.11 |
84 |
9 |
4 |
|
|
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|
a) See additional File 14; b) Linkage to a single DNA marker reported. An arbitrary locus size of 10.0 Mb was assigned. |
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|
Schulz et al. BMC Genomics 2004 5:50 doi:10.1186/1471-2164-5-50 |
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