Mathematical modeling of the likelihood of detecting a genetic modification in B. anthracis. The expected number of hits to an inserted gene of size 1 kb, at 5 copies, was simulated as a function of the number of organism-specific reads collected from the metagenomic sample. The relative size of each rectangle indicates the proportion of samplings for which a specific number of hits is expected.
Frey et al. BMC Genomics 2014 15:96 doi:10.1186/1471-2164-15-96