DEGs in two-way AIC. Two-way AIC detects DEGs as outliers of the gene side and the experiment side. In each direction, outliers are detected by U-value method. Outliers are described as 1 (positive outlier) or -1 (negative outlier). Based on two sets of results for each direction, xi,j in the judgment matrix is set to the value of the label if two labels are the same. Finally it is judged as a DEG (Figure 3).
Tsuyuzaki et al. BMC Genomics 2013 14(Suppl 2):S9 doi:10.1186/1471-2164-14-S2-S9