Table 4

FitSearch can detect genetic interactions that cannot be detected by SGA analysis.

Rank

Gene1

Gene2

Tc

P-value

Note


1

YPL022W RAD1

YML095C RAD10

1

3.44E-29

Single-stranded DNA endonucleases (with each other)

2

YDL040C NAT1

YHR013C ARD1

0.94

1.18E-317

Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)

3

YCR009C RVS161

YDR388W RVS167

0.91

3.37E-114

Manually curated by [27]

4

YPL020C ULP1

YKR082W NUP133

0.91

3.79E-28

Overexpression of ULP1 rescues a nup133 rad27 or nup60 rad27 double mutant [28]

5

YJL194W CDC6

YHR118C ORC6

0.91

1.42E-72

ORC6-rxl and chromosomal deletion of the Cdc6 leads to slow growth phenotype [29]

6

YMR125W STO1

YPL178W CBC2

0.88

2.62E-40

Both are subunits of cap-binding protein complex

7

YMR224C MRE11

YNL250W RAD50

0.88

1.34E-171

MRE11 is a subunit of a complex with Rad50p and Xrs2p

8

YBR175W SWD3

YAR003W SWD1

0.88

4.12E-54

Both are subunits of the COMPASS (Set1C) complex

9

YDR166C SEC5

YLR166C SEC10

0.86

2.30E-32

Both are subunits of the exocyst complex

10

YNL041C COG6

YNL051W COG5

0.8

1.56E-96

Both are components of the conserved oligomeric Golgi complex


The table shows the top 10 results that are not included in the genetic interaction list by SGA analysis [22]. Notes without references are retrieved from the Saccharomyces Genome Database (SGD) [26]. P-values, here, are corrected considering multiple tests.

Lee et al. BMC Genomics 2013 14(Suppl 1):S6   doi:10.1186/1471-2164-14-S1-S6

Open Data