Table 3

Gene ontology analysis for genes demonstrating differential expression over the eight hour LPS timecourse between WKY and WKY.LCrgn2 BMDMs
Gene ontology term (BP_FAT or KEGG pathway) Genes (n) Fold Enrichment Bonferroni corrected P-Value
GO:0010033~response to organic substance 84 2.23 9.00E-09
GO:0009725~response to hormone stimulus 53 2.57 1.59E-06
GO:0009611~response to wounding 46 2.68 6.71E-06
GO:0009719~response to endogenous stimulus 53 2.28 9.90E-05
GO:0001775~cell activation 31 3.18 1.08E-04
GO:0043434~response to peptide hormone stimulus 29 3.24 2.22E-04
GO:0050865~regulation of cell activation 25 3.63 2.44E-04
GO:0002237~response to molecule of bacterial origin 21 4.02 6.34E-04
GO:0002694~regulation of leukocyte activation 23 3.49 0.0018
GO:0032496~response to lipopolysaccharide 19 3.95 0.0036
GO:0045767~regulation of anti-apoptosis 11 7.37 0.0039
GO:0045321~leukocyte activation 26 3.04 0.0039
GO:0001817~regulation of cytokine production 22 3.42 0.0047
GO:0009617~response to bacterium 26 3.00 0.0052
GO:0006954~inflammatory response 26 2.98 0.0056
GO:0048545~response to steroid hormone stimulus 31 2.65 0.0058
GO:0043067~regulation of programmed cell death 54 1.96 0.0079
GO:0010941~regulation of cell death 54 1.96 0.0085
GO:0031667~response to nutrient levels 30 2.64 0.0095
GO:0042981~regulation of apoptosis 53 1.95 0.012
GO:0009991~response to extracellular stimulus 31 2.54 0.014
GO:0002684~positive regulation of immune system process 26 2.80 0.018
GO:0051249~regulation of lymphocyte activation 20 3.37 0.020
GO:0007568~aging 20 3.35 0.022
GO:0006952~defense response 36 2.28 0.024
GO:0045768~positive regulation of anti-apoptosis 9 8.03 0.027
GO:0007565~female pregnancy 16 3.94 0.033
GO:0014070~response to organic cyclic substance 24 2.85 0.033
GO:0008283~cell proliferation 27 2.62 0.036
GO:0046649~lymphocyte activation 21 3.09 0.041
GO:0042592~homeostatic process 53 1.86 0.044

Enrichment for biological process functional annotation terms and KEGG canonical pathways used a Bonferroni corrected p-value threshold of <0.05. Abbreviations: BP_FAT, subset of Biological Process Gene Ontology (GO) terms generated by DAVID; n, number of involved genes.

Hull et al.

Hull et al. BMC Genomics 2013 14:92   doi:10.1186/1471-2164-14-92

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