Email updates

Keep up to date with the latest news and content from BMC Genomics and BioMed Central.

Open Access Methodology article

A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts

Minghui Wang12, Lin Wang1, Ning Jiang13, Tianye Jia2 and Zewei Luo12*

Author Affiliations

1 Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 200433, Shanghai, China

2 School of Biosciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK

3 BioSS Unit, Scottish Crop Research Institute, Invergowrie, DD2 5DA, Dundee, Scotland, UK

For all author emails, please log on.

BMC Genomics 2013, 14:88  doi:10.1186/1471-2164-14-88

Published: 8 February 2013

Additional files

Additional file 1:

Mathematical forms of the coefficients in normal equations (4) and (5).

Format: DOC Size: 133KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Top two principal components from principal component analysis (PCA) of the stage I dataset.

Format: DOC Size: 940KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Association scans from stage II and two-stage combined samples.

Format: DOC Size: 213KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 4:

Scheme A simulation under dominant and recessive genetic models.

Format: DOC Size: 66KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 5:

Structured association using logistic regression.

Format: DOC Size: 111KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 6:

Predicting marker allele frequencies from control samples.

Format: DOC Size: 732KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 7:

Simulation results from using biased estimates of maker allele frequency.

Format: DOC Size: 183KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data