Table 1

Categories over-represented among the EGF regulated genes
Term Count PValue
1 h UP
Dual specificity protein phosphatase 5 7.42E-08
MAP kinase phosphatase 5 4.38E-07
regulation of cell proliferation 22 1.03E-06
MAP kinase tyrosine/serine/threonine phosphatase activity 5 2.34E-06
regulation of transcription from RNA polymerase II promoter 20 4.92E-06
Cell cycle control 14 6.27E-06
regulation of apoptosis 20 2.05E-05
Rhodanese-like 5 2.06E-05
nuclear lumen 24 2.14E-05
Cell proliferation and differentiation 21 2.19E-05
Basic-leucine zipper (bZIP) transcription factor 6 3.16E-05
organelle lumen 27 3.32E-05
vasculature development 11 3.44E-05
response to organic substance 18 6.09E-05
JNK cascade 6 8.69E-05
4 h UP
regulation of cell proliferation 46 4.29E-15
regulation of cell motion 22 1.30E-12
plasma membrane part 68 8.83E-12
cell adhesion 25 1.25E-10
vasculature development 22 1.97E-10
plasma membrane 91 2.71E-10
Focal adhesion 23 2.71E-10
extracellular region part 40 2.87E-10
signal 75 1.24E-09
basement membrane 12 6.78E-09
response to wounding 29 6.99E-09
Signal transduction 85 7.80E-09
integrin binding 11 9.78E-09
24 h UP
Dual specificity protein phosphatase 4 1.07E-05
Secreted 26 2.04E-05
wound healing 10 2.17E-05
angiogenesis 9 2.37E-05
ectoderm development 10 3.00E-05
disulfide bond 36 3.23E-05
EGF-like region, conserved site 11 3.30E-05
MAP kinase phosphatase 4 3.62E-05
heparin-binding 6 4.53E-05
regulation of cell migration 9 6.13E-05
extracellular region part 19 7.79E-05
Skin 26 1.11E-04
epidermis development 9 1.11E-04
signal 37 1.25E-04
MAP kinase tyrosine/serine/threonine phosphatase activity 4 1.43E-04
regulation of cell proliferation 18 1.57E-04
Pathways in cancer 13 1.79E-04
48 h UP
Metallothionein 8 1.21E-12
acetylated amino end 13 2.39E-11
16q13 8 5.32E-10
acetylation 47 1.11E-07
Keratinocyte 11 1.35E-07
response to protein stimulus 9 1.08E-05
peptide cross-linking 5 1.16E-04
Cajal-Retzius cell 9 2.25E-04
Chaperone 8 2.75E-04
Steroid biosynthesis 5 2.81E-04
1q21 5 3.43E-04
Kidney 26 5.22E-04
abdominal aortic aneurysm 5 8.75E-04
1 h DOWN
glycoprotein 81 8.14E-11
signal 67 2.24E-10
plasma membrane part 56 1.11E-09
disulfide bond 59 1.15E-08
Secreted 37 2.93E-06
calcium binding 8 5.58E-05
extracellular region part 26 5.75E-05
regulation of cell motion 11 1.41E-04
Cell adhesion 19 1.62E-04
defense response 20 2.11E-04
calcium 20 2.27E-04
Keratinocyte 8 2.57E-04
sialic acid 4 4.26E-04
disease mutation 30 4.71E-04
Cell junction protein 7 7.65E-04
response to wounding 17 8.70E-04
apical part of cell 9 9.02E-04
4 h DOWN
Ichthyosis 7 3.02E-08
epidermis development 12 2.90E-07
epithelial cell differentiation 9 1.55E-05
cell cycle 12 1.71E-04
Keratinocyte 7 1.95E-04
Metabolism of xenobiotics by cytochrome P450 6 2.24E-04
epidermal cell differentiation 6 2.94E-04
Foreskin 5 4.58E-04
microsome 6 5.75E-04
S100/CaBP-9 k-type, calcium binding 4 9.73E-04
disease mutation 22 9.98E-04
24 h DOWN
Intermediate filament 7 2.11E-06
Insulin-like growth factor binding protein, N-terminal 4 3.13E-05
disease mutation 21 6.00E-05
Thyroglobulin type-1 4 9.49E-05
Structural protein 9 1.06E-04
response to abiotic stimulus 11 1.11E-04
epidermis development 8 1.67E-04
Aldehyde dehydrogenase NAD(P)-dependent 3 1.68E-04
desmosome 4 1.82E-04
response to steroid hormone stimulus 8 2.17E-04
signal 30 4.98E-04
Desmosomal cadherin 3 5.82E-04
response to organic substance 14 5.96E-04
keratin 6 6.72E-04
48 h DOWN
phosphoprotein 120 2.06E-10
response to organic substance 33 1.73E-09
response to endogenous stimulus 24 4.75E-09
regulation of programmed cell death 34 8.33E-09
Cell cycle control 23 1.43E-08
response to steroid hormone stimulus 16 4.35E-08
negative regulation of apoptosis 21 5.63E-08
response to hormone stimulus 21 1.02E-07
apicolateral plasma membrane 11 2.74E-07
Desmosomal cadherin 5 5.95E-07
response to wounding 23 2.37E-06
acetylation 52 5.00E-06
response to extracellular stimulus 14 8.15E-06
response to glucocorticoid stimulus 9 9.28E-06
regulation of cell growth 13 1.16E-05
response to nutrient 11 1.83E-05

Selected categories from DAVID analysis are presented, sorted from the best p-values from each set. UP denotes induced by EGF, DOWN suppressed. Count gives the number of regulated genes in each category.

Blumenberg

Blumenberg BMC Genomics 2013 14:85   doi:10.1186/1471-2164-14-85

Open Data