Resolution:
## Figure 1.
Procedure of encoding the RNA sequences and the amino acid sequences into feature
vectors. a) Procedure of encoding the RNA sequences into feature vectors. For the secondary structure,
RNAsubopt was used to obtain the top six possible secondary structures with the lowest
free energy. The dots and brackets were then replaced by 0 s and 1 s, respectively.
The six vectors were added, and the secondary structure feature vector was obtained.
For Van der Waal’s interaction and hydrogen bonding, each base was replaced by numbers
representing the propensities. Finally, all three feature vectors were transformed
by the Fourier series, and the first 10 terms of Fourier series were used as the new
feature vector. b) Procedure of encoding the amino acid sequences into feature vectors. For the feature
vector of the secondary structure, the corresponding Chou-Fasman propensities were
used to encode each amino acid according to the secondary structure predicted by Predator.
For the feature vectors of hydrogen bonding, each amino acid was replaced by Grantham’s
and Zimmerman’s scores, respectively. Kyte-Doolittle and Bull-Breese scores were used
for Van der Waals’ interaction, respectively. For all five feature vectors, the first
10 terms of the Fourier series were used as new feature vectors.
Lu |