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## Figure 2.
BayMiR performance in the miRNA over-expression experiments. (top) mRNAs in the over-expression miRNA assays are grouped into five bins based
on their BayMiR and gene variation scores; the mean log-fold change of the mRNAs in
each bin is plotted in as a bar. There are two groups of bars; the left- and right-hand
groups correspond to BayMiR and gene variation, respectively. (middle) Comparing BayMiR
and gene variation scores with seven sequence scores from TargetScan. Each bar represents
the negative mean log-fold change for mRNAs whose scores are greater than the median
of all mRNA scores for the selected determinant in the miRNA over-expression assays.
The most left-hand group is obtained by combining the context+ scores with BayMiR
scores. The dashed line shows the mean log-fold change for all targets in the miRNA
over-expression assays (bottom) Comparing BayMiR scores with the conservation scores
as measured by TargetScan. The conservation scores are given only for the targets
with conserved target sites complementary to the seed regions of the conserved miRNA
families. Error bars indicate 95% confidence intervals for the estimated means.
Radfar |