Kernel density estimate of the distances (in bp) between CTCF sites (cCTCF in green and all CTCF sites excluding the cCTCF in red) and their nearest topological domain boundaries. Since more than 90% of the CTCF sites are located inside topological domains, only CTCF sites located inside topological domains were included. We standardized all distances to the median length of all domains in each cell line (680 kb in H1hesc and 840 kb in IMR90). The distances from the nearest boundary at maximum density (vertical lines) are ~19 kb and 25 kb for H1hesc and IMR90 cell lines, respectively.
Li et al. BMC Genomics 2013 14:553 doi:10.1186/1471-2164-14-553