Table 4

Bioinformatic analysis to identify the existence of potential regulations in the C1R-mediated cluster through pathway enrichment analysis
Pathway names Enriched genes in pathway P value Adjust P value
1. Pathway Commons database
Inflammatory Response Pathway IL4R, THBS1 4.42e-05 0.0001
Focal Adhesion ITGA5, SPP1, THBS1 2.93e-05 0.0001
TGF Beta Signaling Pathway SPP1, THBS1 0.0001 0.0002
Senescence and Autophagy CEBPB, THBS1 0.0002 0.0003
Adipogenesis CEBPB, CEBPD 0.0009 0.0009
Initial triggering of complement C1R, CFB 6.60e-05 0.0006
Complement cascade C1R, CFB 6.60e-05 0.0006
Syndecan-4-mediated signaling events ITGA5, THBS1 0.0003 0.0019
IL6-mediated signaling events CEBPB, CEBPD 0.0003 0.0019
Exocytosis of Alpha granule ITGA5, THBS1 0.0003 0.0019
Platelet degranulation ITGA5, THBS1 0.0004 0.0024
IL4-mediated signaling events CEBPB, IL4R 0.0005 0.0026
Response to elevated platelet cytosolic Ca++ ITGA5, THBS1 0.0005 0.0026
Innate Immunity Signaling C1R, CFB 0.0007 0.0030
Platelet Activation ITGA5, THBS1 0.0008 0.0033
Regulation of p38-alpha and p38-beta CEBPB, PTPN1 0.0028 0.0104
Proteogylcan syndecan-mediated signaling events ITGA5, THBS1 0.0035 0.0124
p38 MAPK signaling pathway CEBPB, PTPN1 0.0037 0.0125
Plasma membrane estrogen receptor signaling CEBPB, PTPN1 0.0048 0.0150
BMP receptor signaling CEBPB, PTPN1 0.0053 0.0159
Regulation of nuclear SMAD2/3 signaling CEBPB, PTPN1 0.0101 0.0246
TGF-beta receptor signaling CEBPB, PTPN1 0.0101 0.0246
Regulation of cytoplasmic and nuclear SMAD2/3 signaling CEBPB, PTPN1 0.0101 0.0246
Glypican 1 network CEBPB, PTPN1 0.0224 0.0380
Glypican pathway CEBPB, PTPN1 0.0258 0.0386
2. Wikipathways database
Inflammatory Response Pathway IL4R, THBS1 4.42e-05 0.0001
Focal Adhesion ITGA5, SPP1, THBS1 2.93e-05 0.0001
TGF Beta Signaling Pathway SPP1, THBS1 0.0001 0.0002
Senescence and Autophagy CEBPB, THBS1 0.0002 0.0003
Adipogenesis CEBPB, CEBPD 0.0009 0.0009
3. KEGG database
ECM-receptor interaction ITGA5, SPP1, THBS1 2.75e-06 1.65e-05
Focal adhesion ITGA5, SPP1, THBS1 3.76e-05 0.0001
Cytokine-cytokine receptor interaction IL4R, CXCL2, IL10RB 8.72e-05 0.0002
Complement and coagulation cascades C1R, CFB 0.0002 0.0003
Hematopoietic cell lineage ITGA5, IL4R 0.0004 0.0005
Jak-STAT signaling pathway IL4R, IL10RB 0.0012 0.0012

Zhao et al.

Zhao et al. BMC Genomics 2013 14:46   doi:10.1186/1471-2164-14-46

Open Data