Table 2

Differentially expressed genes in the endometrium that may affect sow prolificacy
Gene Expression Level (TPM) FDR Function
ER LL
PTGS1 14.5 3.64 1.37E-06 − Converts arachidonic acid to  PGH2[28,38].
− Rate-limiting enzymes in PG  synthesis [38].
− Essential to reproduction  [39-43].
PTGS2 5.22 10.92 1.20E-02 − The same as those of PTGS1.
PTGES 91.93 15.10 1.68E-12 − Converts PGH2 to PGE2[30].
PTGES2 25.52 9.64 8.36E-08 − Converts PGH2 to PGE2[44,45].
CBR1 1.16 0.01 1.70E-02 − Converts PGE2 into PGF[46].
CBR2 5.22 141.9 1.17E-136 − Converts PGE2 into PGF  according to KEGG pathway.
RBP4 1160.03 1609.79 7.06E-67 − Transports vitamin A to the  embryos [47], thereby affecting  the growth and development  of the embryos [48].
UF 102.37 1175.01 0.00E-00 − Transports iron to the embryos  [49].
IGF1 0.58 14.01 4.99E-13 − Additively has metabolic,  mitogenic and differentiation  actions and are essential for  prenatal growth of the  conceptus [50,51].
− Control and differentiation of  the uterus for blastocyst  implantation [52].
IGF2 13.92 2.18 2.83E-05 − The same as those of IGF1.
HB-EGF 0.01 1.64 3.62E-02 − Blastocyst growth, and  trophoblast outgrowth [53]  and development [54].
FGF7/KGF 8.70 71.31 3.07E-48 − Proliferation and differentiation  of trophectoderm [55].

See Additional file 7: Table S5 for details of all the differentially expressed genes. Numbers in square brackets are the numbers of the papers in the reference list.

Zhang et al.

Zhang et al. BMC Genomics 2013 14:45   doi:10.1186/1471-2164-14-45

Open Data