Somatic polyG mutation profiles of two mouse littermates. (A) Histogram showing how many different mutant alleles are identified for each marker across all of the approximately 100 cells genotyped for each mouse. An average of 5 mutant alleles was observed on each polyG marker in both mice, yielding an average mutation rate as 0.5 mutant alleles/polyG locus/cell. (B) Histogram showing the number of polyG marker mutations (from all approximately 110 markers) detected per cell for each mouse. For mouse 1, somatic mutations were observed in 36.7% of approximately 110 polyG markers for each single cell clone on average, while in mouse 2, an average of 34.4% were observed. (C) Average genetic distance of different types of tissues to the zygote for each mouse.
Zhou et al. BMC Genomics 2013 14:39 doi:10.1186/1471-2164-14-39