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Open Access Research article

Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Subbiah Rajasekaran, Narsa M Reddy, Wei Zhang and Sekhar P Reddy*

Author Affiliations

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, 830 S. Wood Street, Chicago, IL 60612, USA

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BMC Genomics 2013, 14:381  doi:10.1186/1471-2164-14-381

Published: 7 June 2013

Abstract

Background

The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated that loss of Fra-1 leads to exacerbated bleomycin-induced pulmonary fibrosis, accompanied by enhanced expression of various inflammatory and fibrotic genes. To better understand the molecular mechanisms by which Fra-1 confers protection during bleomycin-induced lung injury, genome-wide mRNA expression profiling was performed.

Results

We found that Fra-1 regulates gene expression programs that include: 1) several cytokines and chemokines involved in inflammation, 2) several genes involved in the extracellular remodeling and cell adhesion, and 3) several genes involved in programmed cell death.

Conclusion

Loss of Fra-1 leads to the enhanced expression of genes regulating inflammation and immune responses and decreased the expression of genes involved in apoptosis, suggesting that this transcription factor distinctly modulates early pro-fibrotic cellular responses.