Open Access Open Badges Research article

Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Subbiah Rajasekaran, Narsa M Reddy, Wei Zhang and Sekhar P Reddy*

Author Affiliations

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, 830 S. Wood Street, Chicago, IL 60612, USA

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BMC Genomics 2013, 14:381  doi:10.1186/1471-2164-14-381

Published: 7 June 2013



The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated that loss of Fra-1 leads to exacerbated bleomycin-induced pulmonary fibrosis, accompanied by enhanced expression of various inflammatory and fibrotic genes. To better understand the molecular mechanisms by which Fra-1 confers protection during bleomycin-induced lung injury, genome-wide mRNA expression profiling was performed.


We found that Fra-1 regulates gene expression programs that include: 1) several cytokines and chemokines involved in inflammation, 2) several genes involved in the extracellular remodeling and cell adhesion, and 3) several genes involved in programmed cell death.


Loss of Fra-1 leads to the enhanced expression of genes regulating inflammation and immune responses and decreased the expression of genes involved in apoptosis, suggesting that this transcription factor distinctly modulates early pro-fibrotic cellular responses.