Table 3

Significantly overrepresented functional annotations describing sleep-enhanced transcripts in the heart
Cluster 1
Category Term P-Value Fold Enrichment FDR(%)
GOTERM_BP_FAT GO:0044265 Cellular macromolecule catabolic process 1.1E-06 2.259 0.002
GOTERM_BP_FAT GO:0019941 Modification-dependent protein catabolic process 3.8E-06 2.328 0.006
GOTERM_BP_FAT GO:0051603 Proteolysis involved in cellular protein catabolic process 4.5E-06 2.278 0.008
GOTERM_BP_FAT GO:0044257 Cellular protein catabolic process 5.2E-06 2.266 0.009
GOTERM_BP_FAT GO:0009057 Macromolecule catabolic process 7.0E-06 2.102 0.012
GOTERM_BP_FAT GO:0030163 Protein catabolic process 1.1E-05 2.188 0.019
SP_PIR_KEYWORDS Ublquitin conjugation pathway 1.9E-05 2.242 0.025
Cluster 2
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Zinc-finger 8.5E-04 1.543 1.147
SP_PIR_KEYWORDS Zinc 1.5E-03 1.393 2.007
SP_PIR_KEYWORDS Metal-binding 2.9E-03 1.293 3.845
Cluster 3
Category Term P-Value Fold Enrichment FDR(%)
GOTERM_BP_FAT GO:0006259 DNA metabolic process 3.0E-05 2.360 0.050
GOTERM_BP_FAT GO:0006281 DNA repair 2.2E-04 2.732 0.363
GOTERM_BP_FAT GO:0006974 Response to DNA damage stimulus 2.8E-04 2.444 0.463
SP_PIR_KEYWORDS DNA damage 5.5E-04 2.720 0.743
SP_PIR_KEYWORDS DNA repair 1.4E-03 2.693 1.914
Cluster 4
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS RNA-binding 1.4E-07 2.568 2E-04
KEGG_PATHWAY Spliceosome 7.3E-05 3.757 9E-02

Sleep enhanced transcripts demonstrate both significantly increased expression in sleep as compared to sleep deprivation (FDR < 1%) and increasing expression as spontaneous sleep progresses (FDR <1%). Overrepresented functional annotations describing this group of transcripts that met a FDR cutoff of 5% are shown. Clusters describe overlapping gene annotations as determined by the DAVID functional clustering feature.

Anafi et al.

Anafi et al. BMC Genomics 2013 14:362   doi:10.1186/1471-2164-14-362

Open Data