Table 1

Significantly overrepresented functional annotations describing sleep-repressed transcripts in the heart
Cluster 1
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Chaperone 7.39E-09 4.992 1.0E-05
SP_PIR_KEYWORDS Stress response 3.39E-08 9.446 4.6E-05
GOTERM_BP_FAT GO:0006457 Protein folding 5.87E-05 3.908 1.0E-01
Cluster 2
Category Term P-Value Fold Enrichment FDR(%)
GOTERM_BP_FAT GO:0043066 Negative regulation of apoptosis 1.13E-06 3.400 0.00195
GOTERM_BP_FAT GO:0043069 Negative regulation of programmed cell death 1.61E-06 3.330 0.00277
GOTERM_BP_FAT GO:0060548 Negative regulation of cell death 1.73E-06 3.316 0.00298
GOTERM_BP_FAT GO:0042981 Regulation of apoptosis 4.09E-05 2.173 0.07051
GOTERM_BP_FAT GO:0043067 Regulation of programmed cell death 5.27E-05 2.145 0.09073
GOTERM_BP_FAT GO:0010941 Regulation of cell death 5.85E-05 2.133 0.10074
GOTERM_BP_FAT GO:0006916 Anti-apoptosis 2.01E-04 4.361 0.34531
Cluster 3
Category Term P-Value Fold Enrichment FDR(%)
GOTERM_BP_FAT GO:0022604 Regulation of cell morphogenesis 1.79E-05 4.725 0.03093
Cluster 4
Category Term P-Value Fold Enrichment FDR(%)
SP_PIR_KEYWORDS Nucleosome core 7.18E-04 6.358 0.97486

Sleep repressed transcripts demonstrate both significantly reduced expression in sleep as compared to sleep deprivation (FDR < 1%) and a decreasing expression as spontaneous sleep progresses (FDR <1%). Overrepresented functional annotations describing this group of transcripts that met a FDR cutoff of 5% are shown. Clusters describe overlapping gene annotations as determined by the DAVID functional clustering feature.

SP_PIR: Swiss-Prot Protein Information Resource; GOTERM_BP_FAT: Gene ontology term Biological process; KEEG: Kyoto Encyclopedia of Genes and Genomes.

Anafi et al.

Anafi et al. BMC Genomics 2013 14:362   doi:10.1186/1471-2164-14-362

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