Table 2

Candidate genes from this study with human homologues implicated in normal and disordered sleep
Human sleep trait or disorder Human gene Sleep trait D. melanogastergene References
Daytime sleepiness PDE4D Day average bout length dunce (dnc) [43]
Night sleep CVE
Waking activity CVE
EYA1 Day average bout length eyes absent (eya) [43]
Day bout number CVE
Usual bedtime OPCML Day average bout length CG31646 [43]
Night sleep CVE
Waking activity CVE
Sleep duration NCOA7 Waking activity l(3)82Fd [43]
Night sleep CVE
Waking activity CVE
Narcolepsy P2RY11 Day sleep CVE peter pan (ppan) [44]
TRIB2 Day bout number CVE tribbles (trbl) [45-47]
[48]
Dscam Day average bout length Down syndrome cell adhesion molecule (Dscam) [49]
Restless Leg Syndrome MEIS1 Waking activity homothorax (hth) [50]
Waking activity CVE
PTPRD Waking activity CVE Leukocyte-antigen-related-like (Lar) [51]
Sleep Apnea ApoE Night sleep nudE [52]
Day average bout length
Night sleep CVE

Harbison et al.

Harbison et al. BMC Genomics 2013 14:281   doi:10.1186/1471-2164-14-281

Open Data