Open Access Research article

Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis

Muna Affara1, Debbie Sanders1, Hiromitsu Araki2, Yoshinori Tamada3, Benjamin J Dunmore1, Sally Humphreys1, Seiya Imoto3, Christopher Savoie2, Satoru Miyano3, Satoru Kuhara4, David Jeffries5, Cristin Print67* and D Stephen Charnock-Jones18*

Author Affiliations

1 Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Robinson Way, Cambridge, CB2 0SW, U.K

2 Systems Pharmacology Research Institute, GNI Ltd., Fukuoka, Japan

3 Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

4 Graduate School of Genetic Resources Technology, Kyushu University, Fukuoka, Japan

5 MRC, The Gambia Unit, Fajara, The Gambia

6 Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand

7 Bioinformatics Institute, University of Auckland, Auckland, New Zealand

8 National Institute for Health Research, Cambridge Comprehensive Biomedical Centre, Cambridge, UK

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BMC Genomics 2013, 14:23  doi:10.1186/1471-2164-14-23

Published: 16 January 2013

Additional files

Additional file 1:

XML file describing the GRN.

Format: XML Size: 7.2MB Download file

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Additional file 2:

List of the parent child relationships inferred from the GRN.

Format: TXT Size: 188KB Download file

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Additional file 3: Figure S1:

The histiogram shows the frequency (y-axis) of number of children (x-axis) in the GRN.

Format: PPT Size: 152KB Download file

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Additional file 4:

List of the 50 hub genes with the largest number of children in the GRN.

Format: DOC Size: 78KB Download file

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Additional file 5:

List of apoptosis associated RNA’s in the Codelink microarray platform and the GRN.

Format: XLSX Size: 61KB Download file

Open Data