Table 2

GO enrichment analysis of eQTL modules/hotspots found by GFlasso
Group eQTL Hotspot eQTL module size GO Category p-value GO size (overlap) GO Annotation [[9]]
Ribi Group *II:560000 722 nucleolus 1.4e-81 224 (148) Cytoplasm organization and biogenesis
ribosome biogenesis 5.4e-62 311 (156)
V:350000 618 ribosome biogenesis 7.0e-104 311 (184)
nucleolus 5.5e-89 224 (129)
V:420000 405 nucleolus 8.0e-80 224 (118)
Ribosome biogenesis 6.8e-66 311 (124)
VII:50000 350 nucleolus 7.6e-97 224 (124)
ribosome biogenesis 5.6e-83 311 (131)
Telomere Group IV:150000 46 cellular component unknown 6.1e-21 683 (33)
helicase activity 1.8e-17 80 (15)
X:20000 48 cellular component unknown 1.6e-22 683 (35)
helicase activity 1.4e-15 80 (14)
XII:780000 44 helicase activity 8.3e-10 80 (15)
cellular component unknown 1.2e-13 683 (26)
*XII:1070000 54 helicase activity 9.3e-19 80 (15) none
cellular component unknown 1.1e-16 683 (27)
Retrotransposon Group V:460000 42 none - -
*VIII:110000 147 conjugation site of polarized growth 1.6e-11 119 (20) conjugation, RNA binding
7.6e-6 211 (18)
XV:90000 85 none - -
Other eQTL modules *II:380000 106 none - -
*III:100000 168 cell. amino acid derivative proc 6.3e-31 215 (55) Organic acid metabolism
transferase activity 2.6e-7 623 (51)
*III:200000 62 conjugation 5.1e-7 119 (10) Response to chemical stimulus
response to chem stimulus 4.3e-6 400 (16)
*V:110000 45 carbohydrate met. process 1.2e-4 249 (9)
cell. aromatic comp. met proc 1.5e-4 65 (5)
XII:610000 53 none - -
*XII:680000 185 lipid metabolic process 1.3e-14 249 (36) Lipid metabolism, ER
ER 3.9e-10 350 (36)
*XIII:70000 76 cell. amino acid derivative proc 1.2e-4 215 (11)
*XIV:450000 448 translation structural molecule activity 2.3e-28 373 (97) Protein biosynthesis, intracellular transport
1.4e-15 325 (7)
XIV:550000 45 none - -
*XV:180000 406 carbohydrate met. process 3.5e-5 249 (36) Gen of precursor met & energy
protein modification process 4.8e-4 544 (21)
*XV:590000 76 gen of precursor met. & energy 2.6e-35 168 (42) Gen of precursor met & energy
mitochondrial envelope 3.8e-20 82 (37)

* denotes a previously discovered hotspot.

Curtis et al.

Curtis et al. BMC Genomics 2013 14:196   doi:10.1186/1471-2164-14-196

Open Data