GO enrichment analysis for eQTL hotspots with overlapping eQTL modules. For both the (a) Ribi group and the (b) Telomere group, we divide all of the genes in the overlapping eQTL modules into different sets (rows) based on which of the eQTL hotspots in each eQTL hotspot group they are mapped to. Genes that map to all four eQTL hotspots are placed in the set labeled “All four” in the top row. Within each of the sets, we show the percentage of genes mapping to the eQTL hotspot(s) that are annotated to one or both of the top GO enrichment categories for the eQTL hotspot group’s eQTL modules along the x axis with different colors. In our analysis, we focus our attention on the genes with associations to three or more eQTL hotspots in a group, as they are enriched for a common function.
Curtis et al. BMC Genomics 2013 14:196 doi:10.1186/1471-2164-14-196