Cancer relevant signaling pathways that the agonistic and antagonistic miRNAs may regulate in human cancers. The lists of genes that positively correlate with either the agonistic or the antagonistic miRNAs (Additional file 11: Table S10) were subjected to an IPA analysis. (A) Genes that inversely correlated with agonists and antagonists fell into four classes, cell cycle regulation, DNA replication, proliferation, and development. (B, C) Genes related to cell cycle regulation (B) and DNA replication (C) whose expression was positively correlated with the agonistic miRNAs and negatively correlated with the antagonistic miRNAs. (D) Genes linked to proliferation whose expression was positively correlated with the antagonistic miRNAs and negatively correlated with the agonistic miRNAs. (B, C, D) The three different colors indicate the three different cancers: green, OvCa; blue, GBM; red, KIRC.
Hua et al. BMC Genomics 2013 14:179 doi:10.1186/1471-2164-14-179