Agonistic and antagonistic miRNAs and their correlating oncogenic gene signatures in three primary cancers. (A) Correlation network between agonistic miRNAs (blue), antagonistic miRNAs (dark green), and 6 oncogenic signatures (light green) shared by OvCa, GBM, and KIRC. (B) Tumor/normal log2 ratio of miRNA expression in primary cancers. From left to right: agonists, antagonists, and EMT regulators. miR-21 is included as a positive control as a miRNA that is upregulated in most human cancers. Stippled lines indicate the 1.5 fold up- or downregulation, taken as the cut-off for genes deregulated in the cancers when compared to matched normal tissues.
Hua et al. BMC Genomics 2013 14:179 doi:10.1186/1471-2164-14-179