Figure 4.

Agonistic and antagonistic miRNAs and their correlating oncogenic gene signatures in three primary cancers. (A) Correlation network between agonistic miRNAs (blue), antagonistic miRNAs (dark green), and 6 oncogenic signatures (light green) shared by OvCa, GBM, and KIRC. (B) Tumor/normal log2 ratio of miRNA expression in primary cancers. From left to right: agonists, antagonists, and EMT regulators. miR-21 is included as a positive control as a miRNA that is upregulated in most human cancers. Stippled lines indicate the 1.5 fold up- or downregulation, taken as the cut-off for genes deregulated in the cancers when compared to matched normal tissues.

Hua et al. BMC Genomics 2013 14:179   doi:10.1186/1471-2164-14-179
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