Figure 4.

MSR array size distribution of MSR5p in the combined (total) population. Top panel: The histogram shows the size frequencies of the MSR5p arrays observed in the combined (total) population. Based on this frequency distribution of the observed data sample the corresponding estimated density of the unknown underlying distribution was calculated, which is displayed on top of the size histogram as a black line (right y-axis). The 95% posterior interval (i.e., the Bayesian counterpart of the 95% confidence interval) of this estimated density is indicated by the grey area. Bottom panel: Based on the estimated density of the unknown underlying distribution (and the uncertainty on this estimated density) the presence of modes and their locations was investigated. The graph shows the posterior probability of a mode for each point in the range of the data. The colors indicate the weight of the mode (i.e., the percentage of probability around the mode between the two surrounding minima) in the following order: weight ≥ 50% (black), 20% ≤ weight < 50% (blue), 10% ≤ weight < 20% (red), weight < 10% (yellow). For MSR5p, the main mode (black) is located around 50 units, two smaller modes (blue/red) around 25 and 75 units and a minor mode (yellow) around 130 units.

Schaap et al. BMC Genomics 2013 14:143   doi:10.1186/1471-2164-14-143
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