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Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

Junwen Wang1, Yudong Xia1, Lili Li2, Desheng Gong1, Yu Yao1, Huijuan Luo1, Hanlin Lu1, Na Yi1, Honglong Wu1, Xiuqing Zhang1, Qian Tao2* and Fei Gao1*

Author Affiliations

1 Science & Technology Department, BGI-Shenzhen, No.11, Bei Shan Industrial Zone, Yantian District, Shenzhen, China

2 Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR, China

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BMC Genomics 2013, 14:11  doi:10.1186/1471-2164-14-11

Published: 16 January 2013

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Contains all supplemental figures (Figures S1-7) and corresponding legends.

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