System diagram of CTF. This figure showed the system diagram of CTF. Different features (PWM, chromatin signatures, and any other features such as the distance to a TSS) were integrated into CTF. Combining these features, CTF called CRF framework to obtain the probability-like scores of TFBSs across the whole genome. The CRF model of CTF contained two states: transcription factor binding site (TFBS) state and non-TFBS (background) state.
He et al. BMC Genomics 2012 13(Suppl 8):S18 doi:10.1186/1471-2164-13-S8-S18