Table 7

Pathways significantly associated with top candidate genes by ToppFun.

Pathway ID/name

Description

Source

p-value

Terms in query

Terms in genome

hsa04080

Neuroactive ligand-receptor interaction

KEGG pathway

5.36 × 10^-5

10

256

REACTOME_GPCR_LIGAND_BINDING

Genes involved in GPCR ligand binding

MSigDB: C2.cp - Reactome

2.66 × 10^-3

10

392

REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

Genes involved in Peptide ligand-binding receptors

MSigDB: C2.cp - Reactome

4.36 × 10^-3

7

173

REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING

Genes involved in Downstream events in GPCR signaling

MSigDB: C2.cp - Reactome

8.63 × 10^-3

10

448

REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS

Genes involved in Class A/1 (Rhodopsin-like receptors)

MSigDB: C2.cp - Reactome

1.62 × 10^-2

8

292

REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

Genes involved in G alpha (q) signaling events

MSigDB: C2.cp - Reactome

2.78 × 10^-2

6

157

Zhao et al. BMC Genomics 2012 13(Suppl 8):S16   doi:10.1186/1471-2164-13-S8-S16