This article is part of the supplement: Eleventh International Conference on Bioinformatics (InCoB2012): Computational Biology

Open Access Proceedings

A computational tool for the design of live attenuated virus vaccine based on microRNA-mediated gene silencing

Duangdao Wichadakul1*, Wuttichai Mhuantong2, Anan Jongkaewwattana3 and Supawadee Ingsriswang1

Author Affiliations

1 Information Systems Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC),113 Thailand Science Park, Phaholyothin Road, Klong 1, Klong Luang, Pathumthani, 12120, Thailand

2 Enzyme Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC),113 Thailand Science Park, Phaholyothin Road, Klong 1, Klong Luang, Pathumthani, 12120, Thailand

3 Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC),113 Thailand Science Park, Phaholyothin Road, Klong 1, Klong Luang, Pathumthani, 12120, Thailand

For all author emails, please log on.

BMC Genomics 2012, 13(Suppl 7):S15  doi:10.1186/1471-2164-13-S7-S15

Published: 13 December 2012

Additional files

Additional file 1:

List of ubiquitously expressed human miRNAs that are conserved with mouse but not chicken.

Format: TXT Size: 5KB Download file

Open Data

Additional file 2:

Number of compiled viral sequences in MicroLive database.

Format: XLSX Size: 43KB Download file

Open Data

Additional file 3:

List of human MREs identified within gene segments of Influenza A H1N1 virus with binding energy lower than -37 KCal/Mol and having at most two amino acid substitutions without effects on physical properties.

Format: XLSX Size: 50KB Download file

Open Data

Additional file 4:

Number of human miRNAs identified with the miranda-predicted MREs within specific viral genes or gene segments.

Format: XLSX Size: 50KB Download file

Open Data