STRING analysis and literature reviews indicated most candidate genes are highly connected and have published cancer associations. STRING analysis is based on several evidences indicating the strength of relationships between pairs of proteins. The STRING output was imported into Cytoscape to depict the network. Darker link denotes stronger relationships. Node colors red, apricot, and white denotes literature search with clinical cancer reports, cancer report but not from clinical samples, and no literature search support found, respectively. Lighter border denotes greater logFC of cancer over normal expression in microarray.
Wu et al. BMC Genomics 2012 13(Suppl 7):S12 doi:10.1186/1471-2164-13-S7-S12