The MS calibration curve. MS ion signal as a function of analyte concentration in solution. The slope of the linear portion of the curve is the instrument response factor (i.e. instrument sensitivity). The curve departs from linear at high analyte concentration. A wider linear dynamic range is desired for quantitative analysis.
Sun et al. BMC Genomics 2012 13(Suppl 6):S2 doi:10.1186/1471-2164-13-S6-S2