Table 3

P53 overlapping cluster membership

Pathway Name, (enrichment p-value)

de novo Gene Membership

de novo Gene Ontology

de novo Protein Interactants

Weighted Consolidation

Enrichment Consolidation


Direct p53 effectors, (p = 1.16 × 10-9)

p53 pathway, (p = 6.19 × 10-9)



p53 signaling pathway, (p = 9.84 × 10-7)



p53-dependent G1 DNAdamage response, (p = 0.15)

n/a

p53-dependent G1/S DNA damage checkpoint, (p = 0.15)

n/a

p53-independent DNA damage response, (p = 0.25)

n/a

p53-independent G1/S DNA damage checkpoint, (p = 0.25)

n/a


Note: matching symbols in a column indicate shared cluster membership. n/a indicates non-enriched pathway not included in any cluster. Dividers and matching symbols indicate pathways groups within a consolidation method.

Doderer et al. BMC Genomics 2012 13(Suppl 6):S18   doi:10.1186/1471-2164-13-S6-S18

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