Hierarchical clustering of expression data at gene level and pathway level. Hierarchical clustering of (A) absolute gene expression over 5 time points; and (B) pathway expression. Gene expression of samples at 5 different time points (TP1 to TP5) are marked above the heatmap, log2-transformed and normalized gene expression data of each gene were plotted in Figure 1A. Average of absolute gene expression over each pathway were evaluated and then plotted in Figure 1B to reflect the activities of biological pathways.
Doderer et al. BMC Genomics 2012 13(Suppl 6):S18 doi:10.1186/1471-2164-13-S6-S18