Table 2

Curation of drug-protein relations from Pub-Med abstracts

Relation

Protein

Drug

PMID

Relation Proof


Up-Regulated

BRCA1

Estradiol

    7553629

"BRCA1 mRNA and protein levels were significantly decreased in estrogen-depleted MCF-7 and BT20T cells and increased again after stimulation with beta-estradiol".

Down-Regulated

P53

Cycloheximide

    9484835

"Treatment of cells with cycloheximide (CHX) prevented the activation of p53 in all phases of the cell cycle and its accumulation in G1/S and S".


Indirect

BRCA1

Hydroxyurea

    9267023

"Hydroxyurea-mediated DNA synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures".

Ambiguous

GCR

Dexamethasone

    12974633

"GRalpha and GRbeta transcripts are coordinately upregulatedin CEM-C7 cells and coordinately downregulated in IM-9 cells by dexamethasone".


Unknown

AKT1

Phosphothreonine

    11087733

The drug-protein relation is not mentioned in the text.


Huang et al. BMC Genomics 2012 13(Suppl 6):S17   doi:10.1186/1471-2164-13-S6-S17

Open Data