Methylation analysis of multiple sample groups. A, Boxplot of noncoding RNA NR_033202 promoter methylation in four groups of AML patients. Multiple-testing corrected non-parametric Kruskal-Wallis analysis of variance p-value is shown. B, Hierarchical clustering dendrogramand heatmap of methylation in gene promoters among four groups of AML patients. The feature threshold criteria were avg rpm > 10 and CV > 5. The full dendrogram generated in R with the pvclust package is included in Additional file 1.
Rodriguez et al. BMC Genomics 2012 13(Suppl 6):S14 doi:10.1186/1471-2164-13-S6-S14