Figure 2.

Updating the reference point. As the search for the optimal drug concentration continues from left to right (from the lowest concentration to the highest one), the reference concentration is updated from the initial drug concentration cmin to the local maximum points xref1, xref2, and xref3, according to this order.

Kim and Yoon BMC Genomics 2012 13(Suppl 6):S12   doi:10.1186/1471-2164-13-S6-S12