Table 2

Selected genes highly mutated in colon cancer tumor genomes

Gene

Protein Accession

Mutations

Protein Length


APC

NP_001120982

76

2843


BRAF

NP_004324

14

766


FBXW7

NP_361014

21

745


KRAS

NP_203524

30

189


LOC440563

NP_001130033

33

293


NRAS

NP_002515

7

189


OR8U1

NP_001005204

48

309


TAS2R19

NP_795369

22

299


TAS2R30

NP_001091112

28

319


TAS2R31

NP_795366

31

309


TAS2R43

NP_795365

36

309


TP53

NP_000537

31

393


Selected list of significantly mutated genes as identified by using local false discovery rate (LFDR) (threshold < 0.1) of the length normalized mutation frequencies for all genes. Mutation counts are the total counts of somatic mutations identified in 100 colon cancer patients falling inside the protein coding region of the gene. Protein length is the number of amino acids in the representative protein isoform for the corresponding gene.

Nehrt et al. BMC Genomics 2012 13(Suppl 4):S9   doi:10.1186/1471-2164-13-S4-S9

Open Data