Table 2

Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily

Group

Disease

Neutral

Total


TK †

496

565

1061

TKL †

172

151

323

Atypical_PI3-PI4 †

49

138

187

CAMK †

40

518

558

Other

36

411

447

RGC †

23

35

58

CMGC †

18

178

196

AGC †

16

190

206

STE

7

222

229

Atypical_ADCK

6

14

20

Atypical_Alpha-type

1

88

89

CK1

1

52

53

NEK

0

45

45

Atypical_RIO

0

14

14

Atypical_PDK-BCKDK

0

5

5

Atypical_FAST

0

1

1


Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily. The groups enriched in disease-associated mutations are highlighted by †.

Izarzugaza et al. BMC Genomics 2012 13(Suppl 4):S3   doi:10.1186/1471-2164-13-S4-S3

Open Data