Table 2

Summary of predicted tissue-specific TF pairs with 3 most significant TF pairs in 22 human tissues

Tissue

# interactions (nonsimilar)

# factors

Top three nonsimilar interactions

Hubs


Bladder*

3 (3)

3

ELK1:NFYA, ELK1:NOBOX, NFYA:NOBOX

-

Blood

6 (4)

5

SPI1:ARID3A, SPIB:ARID3A, SPI1:CTCF

ARID3A, SPI1, SPIB

Bone

24 (24)

25

TBP:TFAP2A, TBP:EWSR1-FLI1, TBP:NOBOX

TBP

Brain

25 (17)

20

SP1:SOX10, SP1:ESR2, SP1:REST

MZF1, SP1

Cervix

40 (30)

24

ZFP423:ZFX, ELK1:ZFX, MIZF:ZFX

ZFX, KLF4, ZFP423

Eye*

4 (2)

6

T:HNF1B, SP1:TAL1-TCF3

SP1

Heart*

6 (5)

7

MEF2A:MAFB, MEF2A:NFKB1, MEF2A:REST

MEF2A

Kidney

95 (87)

64

GATA1:HNF1A, HNF1A:ARID3A, TP53:HNF1B

HNF1A, HNF1B

Liver

106 (99)

67

HNF1A:HNF1B, HNF1A:HNF4A, HNF1A:CEBPA

HNF1A, HNF1B

Lymph node

64 (57)

65

SPI1:MZF1, SPI1:MYF, SPI1:FOXQ1

SPI1

Muscle

41 (38)

40

MEF2A:ZFP423, MEF2A:NHLH1, MEF2A:NFIC

MEF2A, TBP

Pancreas*

14 (13)

15

AR:TAL1-GATA1, MZF1:TAL1-GATA1, E2F1:TAL1-GATA1

TAL1-GATA1

Placenta*

2 (2)

4

RREB1:PDX1, ESRRB:POU5F1

-

PNS*

1 (0)

2

ELK4:REL

-

Sm. intestine*

1 (1)

2

NFYA:TBP

-

Stomach*

7 (6)

8

EWSR1-FLI1:PLAG1, MYC:PLAG1, PAX6:PLAG1

PLAG1

Testis*

16 (14)

19

FOXC1:HOXA5, ARNT-AHR:NOBOX, ARNT-AHR:NKX2-5

ARNT-AHR

Tongue*

12 (11)

16

NFKB1:NFIL3, NFKB1:TFAP2A, GATA3:NKX3-1

NFKB1

Adipose**

104 (90)

46

MZF1:NFYA, NFYA:MYB, NFYA:TBP

NFYA, MZF1

Lymphocyte**

181 (156)

107

ELK1:CEBPA, ELK1:FOXA2, ELK1:POU5F1

NFYA, ELK1, GABPA

Hematop. SC**

50 (41)

36

ELK1:NFYA, NFYA:GABPA, ELK1:EGR1

NFYA, ELK1

Retinal pigm. epithelium**

259 (219)

116

ARNT-AHR:CREB1, ARNT-AHR:NFYA, CREB1:BRCA1

CREB1, NFYA, PAX2


* Network predicted with p ≤ 10-5, ** network predicted with p < 10-10.

Summary of predicted tissue-specific TF pairs (with p-value ≤ 10-6) in 22 human tissues.

Myšičková and Vingron BMC Genomics 2012 13(Suppl 1):S2   doi:10.1186/1471-2164-13-S1-S2

Open Data