Table 3

Highly Expressed SAE-enriched Transcription Factors1

Category

Gene symbol

Gene title

Median expression level (RPKM)


Basic helix-loop

-helix

ATF6B

activating transcription factor 6 beta

26.4

BHLHE40

basic helix-loop-helix family, member e40

16.2

RFX3

regulatory factor X, 3 (influences HLA class II expression)

15.6

HES6

hairy and enhancer of split 6 (Drosophila)

13.6

FOXC1

forkhead box C1

9.3

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

9.1

HEY1

hairy/enhancer-of-split related with YRPW motif 1

9.1

Zinc finger

TRIM29

tripartite motif-containing 29

77.3

KLF5

kruppel-like factor 5 (intestinal)

42.0

RREB1

ras responsive element binding protein 1

7.2

KLF4

kruppel-like factor 4 (gut)

7.1

Helix-turn-helix

FOXJ1

forkhead box J1

363.1

ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific)

170.1

FOXA1

forkhead box A1

62.6

EHF

ets homologous factor

39.1

TBX1

T-box 1

19.7

SATB1

SATB homeobox 1

19.3

MYB

v-myb myeloblastosis viral oncogene homolog (avian)

15.9

SIX2

SIX homeobox 2

13.9

NKX2-1

NK2 homeobox 1

11.6

PHTF1

putative homeodomain transcription factor 1

10.9

TEAD3

TEA domain family member 3

10.9

ETV6

ets variant 6

10.6

FOXA2

forkhead box A2

6.9

β-scaffold

SOX2

SRY (sex determining region Y)-box 2

71.3

RUNX1

runt-related transcription factor 1

16.7

SOX4

SRY (sex determining region Y)-box 4

11.4

TFCP2

transcription factor CP2

10.7

SOX21

SRY (sex determining region Y)-box 21

9.0

NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

7.8

SOX9

SRY (sex determining region Y)-box 9

7.7


1 The top 30 DNA-binding transcription factors were identified in the highly expressed SAE-enriched list for n = 5 healthy nonsmokers. They were categorized by transcription factor family and sorted in descending order of expression within each category.

Hackett et al. BMC Genomics 2012 13:82   doi:10.1186/1471-2164-13-82

Open Data