Open Access Highly Accessed Research article

An integrated approach of comparative genomics and heritability analysis of pig and human on obesity trait: evidence for candidate genes on human chromosome 2

Jaemin Kim1, Taeheon Lee2, Tae-Hun Kim3, Kyung-Tai Lee3* and Heebal Kim124*

Author Affiliations

1 Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea

2 Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

3 Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Suwon, 441-706, Republic of Korea

4 C&K Genomics, Seoul National University Research Park, Seoul, 151-919, Republic of Korea

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BMC Genomics 2012, 13:711  doi:10.1186/1471-2164-13-711

Published: 19 December 2012

Additional files

Additional file 1:

Table S1. Comparative analysis studies of human and pig on obesity-related traits.

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Additional file 2:

Table S3. A Synteny table of the pig and human genomes. Table S4. Number of syntenic SNPs of pig and human by each chromosome. Table S5. Number of autosomal pig SNPs mapped onto Sscrofa 10.2 by each chromosome.

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Additional file 3:

Table S2. Summary of heritability estimates by each chromosome for SUB and BFT traits.

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Additional file 4:

Table S6. Major genes predisposing to common obesity identified from multiple previous works and our study.

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Additional file 5:

Figure S1. Graphical summary (Manhattan plot) of genome-wide association results of SUB (above) and BFT. RASAL2, known as obesity gene, was significantly associated in SUB trait of pig.

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